Abale amagwiritsira ntchito njira yoletsedwa ya ma alchemic potengera munthu kuti amuukitse Trisha atamwalira ndi mliri. Zotsatira zake, kusinthaku kumabwerera kumbuyo komanso mwalamulo ndikusinthanitsa kofanana, mwendo wakumanzere ndi thupi lonse la Alphonse la Edward zawonongeka. Edward adataya mkono wake wakumanja kuti apulumutse moyo wa Alphonse, ndikuumanga kukhala ndi chidindo chamagazi kukhala chovala chankhondo. Roy Mustang akuitana Edward kuti akhale njira yobwezeretsa thupi la Alphonse kuti lifufuzidwe ndi State Alchemist. Edward amapambana, kukhala dzina molingana ndi miyendo yake ya prosthetic, Fullmetal Alchemist.
Patadutsa zaka zitatu, a Elrics amafufuza mwala wodziwika bwino wa Philosopher's kuti akwaniritse zolinga zawo. Marcoh amatumiza zolemba zake kuti amupeze, komabe amaphunzira chofunikira kwambiri kuti Mwalawu ukhale nsembe za anthu. Bwenzi la Mustang, Maes Hughes, amapitiriza kufufuza kwawo, koma amawomberedwa ndi kaduka kobisika kuti apeze njira za Homunculi.
Kuwona ndi Izumi, a Elrics amaphunzira kusintha kwaumunthu kunachitika ndi iye pa mwana wake wobadwa wakufa. Dyera la homunculus Dyera limagwira Alphonse, koma limapulumutsidwa ndi pulezidenti wa Amestris Mfumu Bradley, yomwe ikuwonetsedwa kuti ikugwira ntchito monga homunculus Wrath. Motero umbombo umasungunuka ndi kulowetsedwanso mkati mwa woyambitsa Bambo wa Homunculi. Winry ndi Elrics abwerera ku Central City kuti apite ndi Hughes koma adziwe za kupita kwake. Lieutenant Maria Ross akukonzekera kupha Hughes, koma zikuoneka kuti anaphedwa ndi Mustang. Komabe, Edward adamva kuti Ross adanyamuka kuti amuzembetse ndi Mustang kuchokera ku United States kupita ku Xing, mothandizidwa ndi kalonga wa Xingese Ling Yao. Hohenheim adalumikizananso ndi Edward koma amamunyoza chifukwa chosakhalapo kwa nthawi yayitali.
Pamene nkhaniyo ikupita patsogolo, Homunculi amakumana ndi otsutsa mobwerezabwereza. Mustang amapha chilakolako; Mustang ndi Ling akugwira Gluttony, komabe amathera kaduka mu null yake, ndi Edward, Ling -ngati mimba. Kususuka kumatenga Alphonse kukakumana ndi Atate, koma Ling amasintha kukhala homunculus, makamaka avatar yatsopano kwambiri ya Dyera, pamene ena athawa m'mimba mwa Kususuka. A Elrics amamasulidwa kuti apitirize kufunafuna ngati abambo sangatsutsidwe nawo.
Kupeza ngalande yapansi panthaka pansi pa Briggs, General Olivier Armstrong apeza Abambo ndi Elrics akhala akupanga gulu losinthira dziko ndipo akufuna kupatsa nzika zake kuti athe kukwera kuumulungu. Dyera libwereranso limapandukira abambo ndi zomwe adazikumbukira m'mbuyomu, kugwirizana ndi pambuyo pake, ndi Edward, mafani a chimera a Kimblee Hohenheim. Hohenheim amawulula kwa ana ake aliyense payekhapayekha kuti iye si wachivundi, adasandulika kukhala Mwala wa Philosopher wamoyo ndi Atate zaka mazana anayi zapitazo.
Tsiku Lolonjezedwa lifika ndipo Abambo akukonzekera kuyambitsa njira yawo yokhala ndi kadamsana ndi omwe anayesa kusandulika kwa munthu ngati nsembe zake zofunika. Ma protagonists osiyanasiyana amatsutsana ndi abwenzi a Atate, ndi Homunculi onse akutha. Kutsatira kukakamizidwa kwa Mustang, komanso Elrics, Izumi, Hohenheim amasonkhanitsidwa momwe zomwe zimachititsa kuti abambo ayambitse kusintha kwa dziko. Komabe, Scar ndi Hohenheim amayambitsa ma Amestrian kuti apulumutsidwe ndi zotsutsana. Umbombo umawonongeka ndi Abambo, ngakhale abambo amayang'anizana pamwamba pomwe omenyera nkhondo amalimbana naye kuti agwetse Mwala wa Philosopher.
Alphonse, yemwe zida zake zonse zidawonongeka chifukwa cha nkhondo yomaliza yolimbana ndi Abambo, amapereka mzimu wake kuti apezenso mkono wakumanja, yemwenso amawononga Mwala wa Abambo, ndikumubwezanso ku Chipata cha Choonadi cha Edward. Edward ataya mphamvu zake zopanga alchemy kuti achire mzimu ndi thupi la Alphonse. Hohenheim akuwona manda kumene amamwalira ali ndi grin ya Trisha.
