Yu ☆ Gi ☆ O! Arc-V imakhala mozungulira Yuuya Sakaki, Wodziwika bwino wa Duelist wodziwika kuti "The Phantom" pamodzi ndi ena atatu: Yuuto, Yuugo, ndi Yuuri. Anathamangitsidwa ndi Leo Corporation chifukwa chobowolera mu Masomphenya Olimba ndi misala ndipo adazigwiritsa ntchito pazolinga zake.
Akuthawa, akukumana ndi Yuzu Hiiragi, mwana wamkazi wa wamkulu wa Syu Zo Duel School yemwe anali atatsala pang'ono kutayika ndipo adamupusitsa Yuuya pangano kuti akhale mphunzitsi pasukulu yake. Komabe, Yuuya asanaphunzitse pasukuluyi, choyamba ayenera kupeza khadi yotchedwa Genesis Omega Dragon yomwe idzafotokozere tsogolo la dziko lapansi lomwe limalumikizananso ndi zikumbukiro zake zobalalika.
Nkhaniyi idasinthidwa mu Miami City ina pomwe Leo Corporation, yoyendetsedwa ndi purezidenti wawo Reiji Akaba, ikulamulira gawo lonse la Solid Vision system mumzinda wonsewo. Kufalikira kwa Solid Vision ya kampaniyo ndi misa sikuti kunangobereka "Action Duels" komanso kumathandizira kukonzanso mzindawo kupulumutsa miyoyo ndikukonzanso zowonongeka pakagwa tsoka, kukhala chinthu chofunikira kwambiri
